First off, that isn't Colossus, it's an image of Mimic from Exiles, Issue 3
Colossus - V lived in a world like our own. Taking out a soft, fleshy human is simple. Taking out a mutant with metal skin, not so much?
Tick - Agreed on the toughness factor Blake, as I love both characters. Dr. Strange has demons; The Tick has a capybara named Speak; Dr. Strange has been to Hell and back; The Tick has been through the ends New Jersey and back. Dr. Strange would probably get his butt kicked by Galactus; The Tick was chosen as the janitor of Omnipotus.
Storm - She could blow him into the next state. Wait a sec...
Venom - I'm pretty sure these two have fought before. And I'm pretty sure Venom kicked ass.
Venom & Carnage - While I'm not a fanboy, in the battle of the brain eaters, I go with the team I can actually stand.
Avengers - The earths mightiest heroes vs a bunch of turtles. Do I really need to name the individual avengers who could defeat the TMNT by themselves?