I liked the idea of Survivor where the guy wakes up with amnesia. Too bad the rest of the game blew.
I'd really like to see a horror title where the main character awakens somewhere with no memory whatsoever. And as you journey you learn more and more about who you are, where you are and what happened. Silent Hill might pull it off good since they're the masters of psychological horror. Just as long as the story doesn't take you by the hand and spoon feed you like they did with SH5.
And I'd play the original RE right now just for the cheesy lines!