No More Heroes is a weird game for sure. Super otaku nerd buys beam katana off an online auction to become an assassin? Yup.
People may disagree with me here, but I always felt the Metal Gear Solid games were kind of weird. Especially Metal Gear Solid 3: Snake Eater. I mean most of it was "realistic" in terms of setting and stuff, but look at the villains. Volgin can somehow manipulate and shoot electricity, the Pain CONTROLS BEES... And this kind of stuff is never really explained.
"Snake, he can control hornets and fire them at you like bullets!"
"Okay, I'll be careful!"
Surprised he didnt' say "What the shit?"