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Obnoxious loading screens.
The single-finger prod. There's just not better way to end a game.
Pushover Boss: The third Bowser fight in SM64. After the incredibly awesome level to get to his lair, the fight itself can be done in like 15...
Omaha Beach from MoH:AA
The first Russian missions from CoD
THE BARRENS (kidding)
The first hour of Hellfire Peninsula in WoW